|
KMID : 0357220010130030665
|
|
Journal of Korean Society Physical Therapy
2001 Volume.13 No. 3 p.665 ~ p.676
|
|
|
Comparison of Muscle Atrophy Induced by Cast Fixation,Denervation and Suspension of Rat Hindlimb
|
|
|
|
|
Abstract
|
|
|
The aim of this study was to compare features of muscle atrophy induced by cast fixation, denervation and suspension of rat hind limb. Muscle mass and glycogen of the soleus and plantaris muscles were studied after 3, 7, or 14 days of cast fixation, denervation and suspension.
The results were as follows:
1. Body weight of rats decreased significantly after 3 days and showed gradually increase after 7 and 14 days of hindlimb cast fixation, denervation and suspension. Particularly hindlimb suspended rats showed a rapid decrease after 3 days in body weight.
2. Relative weight of soleus and plantaris muscles decreased significantly by hind limb cast fixation, denervation and suspension, particularly after 7 days. The decrease rate was the lowest in suspended rats.
3.-Glycogen content of soleus muscle decreased significantly after 14 days of hind limb cast fixation, denervation and suspension. Also glycogen content of plantaris muscle decreased significantly after 14 days of hind limb cast fixation and denervation, but not significantly after hind limb suspension.
These results indicate that suspension of hind limb muscles causes less atrophy than cast fixation or denervation, likely due to maintain ment a few activities during hind limb suspension.
We concluded that the decrease in mechanical strains imposed on the muscle during inactivity was the main factor for the development of atrophy. These basic data suggest that some experimental conditions such as electro stimulation or stretching, participate in countermeasure
programs.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|